Investigating genetic predisposition to premature decline in ovarian reserve

Introduction . Normal ovarian reserve (OR) determining the response to follicle development containing fully-featured oocytes is an important factor in pregnancy, including assisted reproductive technology (ART) programs. The causes of premature OR decrease are multifactorial. study gene polymorphism as a cause deserves attention. Aim : determine genetic predisposition and create prognostic model based on results. Materials Methods. A retrospective comparative cohort was conducted. total 200 reproductively active patients with infertility underwent ART were examined. divided into 2 groups: Group 1 included 100 decrease; consisted normal OR. All molecular study. Genetic polymorphisms genes ESR1, ESR2, FSHR, CYP19A studied. Results final clinical phenotype shaped by multiple factors – environmental. Several variants contribute formation reserve. Gene combination CYP19A1 FSHR displayed greatest synergistic effect, potentiating each other predisposing poor part stimulated superovulation. Conclusion Identifying markers promising method for individual evaluation, its decline. Multilocus analysis combining several polymorphic will allow assess risks individualize